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Diazepam, first marketed as Valium, is a drug in the benzodiazepine family that usually has a calming effect. It is commonly used to treat a variety of conditions, including anxiety, seizures, alcohol withdrawal syndrome, benzodiazepine withdrawal syndrome, muscle spasms, sleep problems and restless legs syndrome. It can also be used to cause memory loss during certain medical procedures. It can be taken by mouth, inserted into the rectum, injected into muscles, injected into a vein or used as a nasal spray. When given into a vein, the effects begin in one to five minutes and last up to an hour. At the mouth, the effects begin after 15 to 60 minutes.
Common side effects include drowsiness and coordination problems.   Serious side effects are rare.  They include suicide, decreased respiration, and an increased risk of seizures if used too often in people with epilepsy. Occasionally, tension or agitation may occur. Long-term use may lead to tolerance, dependence, and withdrawal symptoms on dose reduction. Abrupt stoppage after prolonged use can be potentially dangerous. After interruption, cognitive problems may persist for six months or longer. It is not recommended during pregnancy or lactation. That mechanism of action is by increasing the effect of the neurotransmitter gamma-aminobutyric acid (GABA).
Diazepam was patented in 1959 by Hoffmann-La Roche. It has been one of the most prescribed drugs in the world since its launch in 1963. In the United States, it was the best-selling drug between 1968 and 1982, selling more than two billion tablets in 1978.  In 2017, it was the 135th most commonly prescribed drug medicine in the United States, with more than five million prescriptions. The patent expired in 1985, and there are now more than 500 brands available on the market.  It is on the World Health Organization’s list of important medicines. The wholesale cost in the developing world is about 0.01 USD per dose as of 2014.  In the US it is about 0.40 USD per dose, Buy Stesolid in Sweden